What is the required media fill testing frequency for low/medium risk inpatient compounding?

• A. Every 6 Months
• B. Every 4 Months
• C. Yearly
• D. Every 12 Months

Answer: (A)

Media fill testing checks that aseptic technique and the sterile environment actually prevent contamination during compounding. For low- and medium-risk inpatient compounding, the ongoing verification is done every six months. This semi-annual interval provides regular confirmation that staff maintain proper aseptic skills over time, while not being so frequent as to be overly burdensome. If there are significant changes—such as new personnel, changes in gowning or cleaning procedures, or a recent deviation in technique—testing should be performed sooner.