The term "legend drugs" refers to drugs that require what?

• A. A prescription from a licensed practitioner
• B. No prescription
• C. Investigational status
• D. Controlled substance status

Answer: (A)

Legend drugs are medications that require a prescription from a licensed practitioner. This designation means the drug’s safety, dosing, and potential risks need medical oversight, so it isn’t sold over the counter. The clinician must assess the patient, determine the need for the drug, and monitor therapy. This is separate from investigational status (drugs still in trials) or from controlled substance status (which involves additional regulatory controls for potential abuse). Thus, the defining requirement is that a licensed clinician prescribes the medication.